Beyond Lipids: Antiarrhythmic Effects of Statins

Effects of Plasma Lipids and Statins on Cognitive Function

Objective: Dementia is the fourth most common cause of death in developed countries. The relationship between plasma lipids and cognitive function is complex and controversial. Due to the increasing life expectancy of the population, there is an urgent need to control vascular risk factors and to identify therapies to prevent and treat both cognitive impairment and dementia. Here, we reviewed t...

Matter of Fat: Are Lipids Antiarrhythmic?

Beyond lipid lowering: pleiotropic effects of statins in heart failure

In the 1980s, statins were introduced in clinical practice as lipidloweringmedication. Since then, several additional, pleiotropic, effects of statins have been described, including angiogenic, antiarrhythmic, antibacterial, anti-inflammatory, antimitotic, antioxidative, antithrombotic, CRP-lowering, immunomodulatory and vascular protective (stabilisation of the atheroma plaque) activity, inhib...

Anti-Inflammatory Effects of Statins Beyond Cholesterol Lowering

Statins lower low density lipoprotein-cholesterol (LDL-C) level by inhibiting 3-hydroxy-methylglutaryl coenzyme A (HMG-CoA) reductase. A meta-analysis of the primary and secondary prevention trials of statin therapy demonstrated the reduction of major coronary events, coronary revascularization, and stroke by 20% per 1 mmol/L (39 mg/dL) reduction in LDL-C levels, and a linear relationship was s...

Beyond blood lipids: phytosterols, statins and omega-3 polyunsaturated fatty acid therapy for hyperlipidemia.

Phytosterols and omega-3 fatty acids are natural compounds with potential cardiovascular benefits. Phytosterols inhibit cholesterol absorption, thereby reducing total- and LDL cholesterol. A number of clinical trials have established that the consumption of 1.5-2.0 g/day of phytosterols can result in a 10-15% reduction in LDL cholesterol in as short as a 3-week period in hyperlipidemic populati...